Orlistat, marketed as Xenical in prescription strength (120 mg) and Alli in over-the-counter form (60 mg), remains one of the most established and widely used non-systemic weight loss medications in 2026. Unlike appetite suppressants or GLP-1 injections that act on the brain, orlistat works locally in the gastrointestinal tract by inhibiting gastric and pancreatic lipases—the […]