Phentermine-topiramate, marketed as Qsymia, remains one of the most effective FDA-approved combination medications for long-term weight management in 2026. This once-daily oral capsule pairs phentermine—a sympathomimetic amine that suppresses appetite by stimulating norepinephrine release in the hypothalamus—with topiramate, an anticonvulsant that enhances GABA activity, modulates glutamate, and reduces food cravings. Together, the two agents target […]